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Laron syndrome
Laron's syndrome, or Laron-type dwarfism, is an autosomal recessive disorder characterized by an insensitivity to growth hormone (GH), usually caused by a mutant growth hormone receptor. It causes short stature and a resistance to insulin or even a rare form of diabetes mellitus type 2 and cancer. It can be treated with injections of recombinant IGF-1.
==Eponym==
It is named after Zvi Laron, the Israeli researcher who, with A. Pertzelan and S. Mannheimer, first reported the condition in 1966, based upon observations which began in 1958.
Resistance to GH was first reported by Laron in 1966. Since then, severe resistance to GH, characterized by grossly impaired growth despite normal levels of GH in serum, has been termed Laron syndrome.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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